Aox_Part+II_Student - Cancer Chapter 18 cancer development...

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Cancer Chapter 18
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cancer development
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Why do cancers develop? Genetic defect affecting DNA structure, function or repair DNA damage caused by oxidants produced by immune cells rate of cell division due to chronic inflammation Exposure to carcinogens
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carcinogenesis = development of cancer Arises from mutations in genes that control cell division in single cell Promote cellular growth Interfere w/ growth restraint Prevent cellular death Propagates
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Carcinogens Radiation sun Water & air pollution smoking Lack of physical activity (colon, breast cancer) Obesity Ex: Fat tissue produces estrogen extended estrogen exposure in obese women
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Initiators Up to 1/3 of all cancer cases diet-related? Tobacco use + alcohol + low intake of yellow and green fruits and vegetables = risk of head and neck cancers alcohol use raises risk of liver, mouth, throat & breast cancer Weigh cardiovascular benefit w/ cancer risk
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INITIATORS (CONT’D)
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This note was uploaded on 01/26/2012 for the course NTDT 200 taught by Professor Aljadir during the Fall '08 term at University of Delaware.

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Aox_Part+II_Student - Cancer Chapter 18 cancer development...

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