Blood+health_S10 - Trivia What is the leading cause of...

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1 Trivia What is the leading cause of accidental poisoning in small children? iron toxicity from consuming vitamins w/ iron
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2 Blood health
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3 Nutrients involved in blood health Folate Vitamin B12 Vitamin K (revisited) Iron
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4 Folate Coenzyme: THF (tetrahydrofolate) 1.In foods, folate usually bound to glutamate polyglutamate 2.Monoglutamate absorbed in small intestine 3.Methyl group attached
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5 Folate trap Vitamin B12 needed to remove methyl group in order for THF to function If vitamin B12 deficiency, methylated folate trapped in cell DNA synthesis and cell growth impaired
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7
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8 Dietary folate equivalents (DFE) 50% bioavailability from foods 100% bioavailability for supplements taken on empty stomach (monoglutamate form) DFE = mcg food intake + (1.7 x mcg synthetic folate) Ex: 100 mcg from food + 100 mcg from supplement How many DFE? What counts as supplement?
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9 Folate and neural tube defects Folate drastically reduces neural tube defects (spina bifida and anencephaly) if consumed in adequate amounts: 1 month before conception Throughout 1 st trimester of pregnancy
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10 Spina bifida
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11 Folate fortification ½ of pregnancies unplanned Neural tube defects occur often before women realize they are pregnant Since 1996, grain products fortified with folate
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12 Neural tube defects
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13 Folate and heart disease Without folate, homocysteine accumulates Appears to promote blood clot formation Appears to promote arterial wall deterioration Supplements not shown to reduce risk of death from CVD
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14 Folate deficiency Megaloblastic or macrocytic anemia Impaired oxygen-carrying ability & impaired travel through capillaries
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15 Normal vs. megaloblastic RBCs
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This note was uploaded on 01/26/2012 for the course NTDT 200 taught by Professor Aljadir during the Fall '08 term at University of Delaware.

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Blood+health_S10 - Trivia What is the leading cause of...

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