CVD+and+proteins_S10_Student

CVD+and+proteins_S10_Student - Cardiovascular disease...

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Unformatted text preview: Cardiovascular disease Chapter 18 10 leading causes of death Coronary heart disease (CHD)-M ost common form ost common form of CVD of CVD-Caused by -Caused by atherosclerosis atherosclerosis (hardening) of (hardening) of coronary arteries coronary arteries atherosclerosis Soft, fatty streaks develop along inner arterial walls Streaks enlarge, harden, fill w/ Ca, cholesterol & other lipids _plaques_ Japanese study showed atherosclerotic plaque in children as young as _2_ High _saturated fat (SFA)_intake associated w/ plaque formation Plaque on artery walls leads to _atherosclerosis_ Plaque formation High _LDL, HTN_, toxins from cigarette smoke, high homocysteine levels, or some viral or bacterial infections damage lining of blood vessels _Inflammatory_ response activated _LDL_ particles become trapped, get oxidized by free radicals, & engulfed by macrophages become cells of plaque Plaque rupture Sudden spasm or surge in _BP_ can damage covering of plaque _rupture_ _Composition_of plaque, not size, determines likelihood of rupture Ruptured plaque causes _clot_ formation Blood clots _Thrombosis_ Clot grows large enough to restrict blood flow or block blood vessel completely MI or stroke _Embolism_ Clot breaks free from arterial wall travels through circulatory system shuts off blood flow to surrounding tissues Causes MI or stroke _C-Reactive protein_...
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This note was uploaded on 01/26/2012 for the course NTDT 200 taught by Professor Aljadir during the Fall '08 term at University of Delaware.

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CVD+and+proteins_S10_Student - Cardiovascular disease...

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