Asprin - an inorganic acid as a catalyst. The reaction...

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I. Introduction Aspirin or acetylsalicylic acid is a derivative of salicylic acid that is a mild, non-narcotic analgesic useful in the relief of headache, muscle, and joint aches. The drug works by inhibiting the production of prostaglandins, body chemicals that are necessary for blood clotting and which also sensitize nerve endings to pain. A German chemist named Felix Hoffman is credited with being the first to synthesize aspirin in 1897. Hoffman's father had severe arthritis but could not tolerate salicylic acid he was taking for pain relief. Friedrich Bayer, the employer of Hoffman, patented the name and began marketing the product in 1899. It was a huge success and sales grew rapidly. Bayer's company set up by himself, is generally reckoned to have been the first pharmaceutical company, and the production of aspirin is generally accepted to have laid the foundation of the modern pharmaceutical industry Aspirin can be prepared by the reaction of acetic anhydride and salicylic acid in the presence of
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Unformatted text preview: an inorganic acid as a catalyst. The reaction takes place at the phenol functional group. In this series of experiment, salicylic acid will undergo organic synthesis to produce aspirin. Organic synthesis is a special branch of chemical synthesis and is concerned with the construction of organic compounds via organic reactions. Organic molecules can often contain a higher level of complexity compared to purely inorganic compounds, so the synthesis of organic compounds has developed into one of the most important branches of organic chemistry. II. Objectives At the end of the exercise, the student should be able to: 1. be introduced to the concept of organic synthesis; 2. synthesize acetylsalicylic acid from salicylic acid by nucleophilic acyl substitution; and 3. differentiate acetylsalicylic acid from salicylic acid by simple chemical tests....
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