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Calcitonin - Skeletal System Calcitonin A hormone secreted...

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Skeletal System Calcitonin * A hormone secreted by C cells in the thyroid gland. * Secreted when blood calcium raises too high * Lowers blood levels by two mechanisms * osteoclast inhibition- reduces osteoclast activity * increases the number of osteoblast to deposit calcium into the skeleton * Osteoclast inhibition is very important in children over adults because * osteoclast activity contributes to 5g of blood calcium each day * activity in adults only contributes .8g of blood calcium per day * Calcitonin deficiency in adults is not known to cause disease * Useful in reducing bone loss in pregnant and lactating women and in the condition of osteoporosis Parathyroid Hormone * Secreted by parathyroid glands * Secreted when blood calcium is too low * Raises blood calcium by four mechanism * stimulates the release of osteoclast-stimlating factor by osteoblast causing increased numbers of osteoclast * promotes calcium reabsorption by the kidney * increases synthesis of vitamin D *
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