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Cell Polarity - Tissue Cell Polarity Epithelial cells have...

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Tissue Cell Polarity * Epithelial cells have distinct polarity * Apical domain- is always directed toward the exterior surface or the lumen of an enclosed cavity or tube * Lateral domain- communicates with adjacent cells and is characterized by specialized attachment areas. * Basal domain- rests on the basal lamina anchoring the cell to underlying connective tissue. Apical Domain And Its Modifications * Structural modifications * Microvilli- cytoplasmic process that extend from the cell surface * Stereocilia (stereovilli)- microvilli of unusual length * Cilia- motile cytoplasmic processes * Other specialized entities * Specific enzymes (ex: hydrolases) * Ion channels and carrier proteins (ex: glucose transporters) Microvilli * Increases the apical surface area * The number and shape of microvilli correlates with its absorptive capacity * In intestine called striated border * In kidney called brush border Actin in Microvilli * Anchored by a binding protein called villin , located at the tip of the microvillus *
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