CHOLINERGIC MUSCARINIC RECEPTORS

CHOLINERGIC MUSCARINIC RECEPTORS - Autonomic Nervous System...

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Autonomic Nervous System CHOLINERGIC MUSCARINIC RECEPTORS * Mechanism of action is indirect * Muscarinic receptors belong to a class of receptors which use G proteins as their signalling mechanism, which begin an information cascade within the cell. Adrenergic Receptors * Two classes * alpha (α) - usually exitatory * beta (β) - usually inhibitory * There are exceptions to the above and it is due to the existence of subclasses of each receptor type: α 1 α 2 β 1 , β 2 * all four types function by means of second messengers * both β receptors activate the production of cyclic AMP * α 2 suppress cAMP production and α 1 employ calcium ions as the second messenger * Stimulation of beta- or alph2-receptors leads to activation of Gs or Gi, which then act as transducers to activate ,Gs, or inhibit ,Gi, adenylyl cyclase. This results in increased or decreased production of cAMP from ATP * alph1-Receptor s work through Gp, which activates phospholipase C to promote conversion of phosphatidyl inositol bisphosphate ,PIP2, to diacyl
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This note was uploaded on 01/30/2012 for the course BSC BSC1085 taught by Professor Sharonsimpson during the Fall '10 term at Broward College.

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CHOLINERGIC MUSCARINIC RECEPTORS - Autonomic Nervous System...

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