Electrical Activity of Neurons Communication among neurons is based upon specialized mechanisms for producing electrical potentials and currents . All living cells are polarized , but only specific types of cells are excitable . In contrast to the resting membrane potential of muscle , the RMP of neurons is ~ -70 mV. The RMP is the result of several different conditions. 1) The selective permeability of neurons results in an unequal electrolyte distribution across the cell membrane. Na + is highly concentrated outside of the cell while K + and impermeant anions are concentrated inside the cell. 2) The selective permeability of the plasma membrane also allows the facilitated diffusion of some ions down their concentration gradients. Specifically, neurons are permeable to K + and K + leaks out through "leaky " channels. This removes positive ions from the inside of the cell. 3) The constant working of the electrogenic Na + /K + pump removes 3 Na + from the cell for every 2 K + it brings in resulting in the net movement of one positive charge from the cell. Recall that during depolarization the potential
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