Glomerular and Capsular Pressures

Glomerular and Capsular Pressures - (nephrosclerosis) and...

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Urinary System Glomerular and Capsular Pressures * The hydrostatic pressure in the capsular space is about 18mm Hg compared with the slightly negative interstitial pressure elsewhere * Resulting from the high rate of filtration occurring here and the continual accumulation of fluid in the capsule * The colloid osmotic pressure (COP) of the blood is about the same here as anywhere else (32mm Hg) * The glomerular filtrate is almost protein-free and has no significant COP * This can change markedly in kidney diseases that allow protein to filter into the capsular space * Result, high outward pressure of 60mm Hg, opposed by inward pressures of 18 and 32mm Hg giving a net filtration pressure (NFP) of 10mm Hg Nephrosclerosis * High blood pressure in the glomeruli makes the kidneys especially vulnerable to hypertension, which can rupture glomerular capillaries and lead to scarring of the kidney
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Unformatted text preview: (nephrosclerosis) and atherosclerosis of renal blood vessels, leading to renal failure Glomerular Filtration Rate * Is the amount of filtrate formed per minute by the two kidneys combined. * Filtration coefficient (Kf)- for every 1mm Hg of net filtration pressure, the kidney produce about 12.5 mL of filtrate per minute * Filtration coefficient depends upon * Permeability of the filtration barrier * Surface area of the filtration barrier * GFR = NFP X Kf = 10 X 12.5 = 125mL/min * Females have a 10% lower Kf, therefore they calculate at 105mL/min * The approx. filtrate produced is a rate of 180 L/day in males and 150 L/min in females. * 99% of the filtrate is reabsorbed and approx. 1-2 L of urine are excreted per day...
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This note was uploaded on 01/30/2012 for the course BSC BSC1085 taught by Professor Sharonsimpson during the Fall '10 term at Broward College.

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