Hemoglobin - Hemoglobin Hemoglobin is a protein that...

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Hemoglobin Hemoglobin is a protein that consists of four polypeptide chains called globins . Each polypeptide chain is conjugated with a heme group (hence hemo--globin). (See Figure 4). Each heme group, bound to iron, can then bind to an oxygen molecule; thus each hemoglobin can bind to four O 2 . Figure 4 Erythrocyte Death and Disposal Barring any external trauma that results in damage, RBCs generally live for ~120 days. Without internal organelles, RBCs lack normal cellular repair mechanisms; thus as they age, they lose flexibility and the fragility of their membranes increase. The capillaries in the spleen and liver are so narrow that if a red blood cells is inflexible or damaged it is removed from the circulation and degraded by macrophages . The membrane and globin portion of hemoglobin is digested and recycled. Much of the iron is also recycled. Heme (without iron) is converted into the bile pigments biliverdin and bilirubin , which are excreted through the feces. Blood Types
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This note was uploaded on 01/30/2012 for the course BSC BSC1085 taught by Professor Sharonsimpson during the Fall '10 term at Broward College.

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