Hormonal Regulation of Spermatogenesis

Hormonal Regulation of Spermatogenesis - sustentacular...

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Hormonal Regulation of Spermatogenesis The processes of spermatogenesis and spermiogenesis are hormonally regulated via the hypothalamic-pituitary-testicular axis. Hypothalamic gonadotropin-releasing hormone stimulates the secretion of the gonadotropins -- follicle-stimulating hormone and luteinizing hormone from the anterior pituitary gland. FSH stimulates the sustentacular cells to release androgen binding protein , which enables developing sperm to bind and respond to testosterone and its derivatives. LH/ISH stimulates the interstitial cells to produce testosterone which is required for spermatic development (spermatic development also requires ABP from the sustentacular cells). Thus, the
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Unformatted text preview: sustentacular cells facilitate sperm production by enabling them to respond to the testosterone secreted from the interstitial cells. FSH and LH secretion is regulated via negative feedback, where increased levels of FSH, LH and testosterone inhibits the secretion of additional FSH and LH (as well as inhibiting the secretion of GnRH). (See Figure 4) The hormone inhibin is secreted when it is necessary to reduce sperm production, but not testosterone levels. It specifically inhibits FSH secretion, therefore decreasing ABP production and the sensitivity of developing spermatocytes to testosterone. Figure 4...
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This note was uploaded on 01/30/2012 for the course BSC BSC1085 taught by Professor Sharonsimpson during the Fall '10 term at Broward College.

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