{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Hormonal Regulation of Spermatogenesis

Hormonal Regulation of Spermatogenesis - sustentacular...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Hormonal Regulation of Spermatogenesis The processes of spermatogenesis and spermiogenesis are hormonally regulated via the hypothalamic-pituitary-testicular axis. Hypothalamic gonadotropin-releasing hormone stimulates the secretion of the gonadotropins -- follicle-stimulating hormone and luteinizing hormone from the anterior pituitary gland. FSH stimulates the sustentacular cells to release androgen binding protein , which enables developing sperm to bind and respond to testosterone and its derivatives. LH/ISH stimulates the interstitial cells to produce testosterone which is required for spermatic development (spermatic development also requires ABP from the sustentacular cells). Thus, the
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: sustentacular cells facilitate sperm production by enabling them to respond to the testosterone secreted from the interstitial cells. FSH and LH secretion is regulated via negative feedback, where increased levels of FSH, LH and testosterone inhibits the secretion of additional FSH and LH (as well as inhibiting the secretion of GnRH). (See Figure 4) The hormone inhibin is secreted when it is necessary to reduce sperm production, but not testosterone levels. It specifically inhibits FSH secretion, therefore decreasing ABP production and the sensitivity of developing spermatocytes to testosterone. Figure 4...
View Full Document

{[ snackBarMessage ]}