Platelet Plug - Platelet Plug When stimulated by exposure...

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Platelet Plug When stimulated by exposure to the underlying connective tissues, platelets become sticky and clump together forming a structure known as a platelet plug. Without damage, the endothelial lining of blood vessels is coated with a chemical known as prostacyclin . Prostacyclin is a platelet repulsion chemical and keeps platelets from sticking to each other and to undamaged blood vessel walls. Damaged vessels break the prostacyclin coating and expose the platelets to the collagen of the underlying connective tissue. Platelets begin to stick to the site of damage and attract additional platelets to the site by degranulation . Platelets release serotonin, adenosine diphosphate and thromboxane A 2 . Serotonin is a vasoconstrictor, adenosine diphosphate attracts and degranulates more platelets, and thromboxane A 2 promotes aggregation , degranulation of more platelets and additional vasoconstriction. (See Figure 6). Figure 6
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This note was uploaded on 01/30/2012 for the course BSC BSC1085 taught by Professor Sharonsimpson during the Fall '10 term at Broward College.

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Platelet Plug - Platelet Plug When stimulated by exposure...

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