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Unformatted text preview: in the plasma. At increasing distances from the damaged area, the amount of activated thrombin present will decrease because of dilution and the activity of antithrombin, decreasing the amount of fibrin formation. Fibrinolysis Immediately following clot formation, tissue repair mechanisms are activated. Platelet-derived growth factor secreted by platelets stimulates mitotis in fibroblasts and smooth muscles to repair the damaged vessel. Afer tissue repair, the clot becomes unnecessary, and possibly dangerous. Fibrinolysis is the process by which fibrin clots are dissolved. Kallikrein and factor XII activate the plasma protein plasminogen . Plasminogen is converted into plasmin , a fibrin-dissolving enzyme, that breaks down the fibrin net....
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- Fall '10