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Unformatted text preview: * There are two mechanisms of autoregulation * Myogenic mechanism * Tubuloglomerular feedback Myogenic Mechanism * Keeping mind that GFR = Pgc (filtration pressure) x Kuf (ultrafiltration coefficient) and filtration pressure is a matter of blood pressure (or glomerular capillary pressure) * Blood pressure changes are sensed through stretch receptors and respond accordingly through relaxation or constriction. * afferent arteriolar vasoconstriction would serve to protect the glomerulus from uncontrolled systemic hypertension, * while afferent arteriolar vasodilatation would allow for greater blood flow into the glomerulus in times of hypotension * The autoregulatory system accomplishes this by maintaining the glomerular capillary pressure around 60-70 mm Hg * This ability to maintain renal perfusion pressure and glomerular capillary pressure is impaired when mean arterial pressure drops below 70 mmHg....
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- Fall '10