Stomach1 - producing a different chemical messenger Stomach...

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Digestive System Stomach: Glands * Regenerative (stem) cells * Found in the base of the pit and neck of gland * Undergo mitosis to produce new cells * Newly generated cells migrate up as well as downward into the glands to replace cells that die Stomach: Glands * Parietal cell * Found mostly in the upper half of the gland * Secrete HCl and intrinsic factor * Found mostly in the gastric glands, but a few occur in the pyloric glands Stomach: Glands * Chief Cells * Are the most numerous * Secreted in infancy * Chymosin ( also known as rennin)- is a proteolytic enzyme whose role in digestion is to curdle or coagulate milk in the stomach * Lipase- digest the butterfat of milk * pepsinogen * secretes throughout life * Activated to pepsin by HCl * They dominate the lower half of the gastric glands but are absent from cardiac and pyloric glands Stomach: Glands * Enteroendocrine cells * Concentrated especially in the lower half of glands throughout the stomach * Secrete hormones and paracrine messengers that regulate digestion * There are at least eight different kinds of enteroendocrine cells in the stomach, each
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Unformatted text preview: producing a different chemical messenger Stomach Histology: Stomach * The parietal cells (Oxyntic Cells) are easily seen as large, eosinophilic cells scattered in a background of more basophilic chief cells. * These are very easy to identify because they look like "fried eggs", * the other type of cells are Chief Cells, Histology: Stomach * The parietal cell ( PC ) is large, round, and eosinophilic, thanks to its cytoplasmic complement of mitochondria. Since these cells have a high demand for ATP to drive the pumps that push sodium out of the cytoplasm into the lumen of the stomach, mitochondria are abundant. Digestive System * The chief cell ( CC ) has deeply basophilic basal regions, indicative of the presence of large amounts of RER. At its apical end, the chief cell has granular inclusions; these are the packets of enzymes waiting to be released....
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Stomach1 - producing a different chemical messenger Stomach...

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