Tubuloglomerular Feedback

Tubuloglomerular Feedback - Urinary System Tubuloglomerular...

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Urinary System Tubuloglomerular Feedback * Juxtaglomerular apparatus is made up of specialized cells in the wall of the afferent arteriole and granular cells in the wall of the distal tubule (the macula densa ). * This area is innervated by adrenergic fibers and the granular cells carry renin in intracellular granules Tubuloglomerular Feedback * The principle function of the JGA is adapting the GFR to early distal tubule fluid characteristics by modulating renin synthesis and release: this is known as the tubuloglomerular feedback (TGF) loop. * Afferent arteriolar caliber is principally controlled by TGF * Besides altered sodium concentration at the macula densa of the distal tubule, release of renin can also be induced by changes in the blood flow patterns of the afferent arteriole, or by adrenergic stimulation . Renin-Angiotensin Mechanism * When blood pressure drops, the sympathetic nerves stimulate the JGA cells to secrete renin * Renin acts on angiotinsinogen to create angiotensin. * Angiotensin is converted to angiotensin II by the action of angiotensin-converting
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This note was uploaded on 01/30/2012 for the course BSC BSC1085 taught by Professor Sharonsimpson during the Fall '10 term at Broward College.

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Tubuloglomerular Feedback - Urinary System Tubuloglomerular...

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