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Unformatted text preview: of the glomerular podocytes and the basement membranes between the two. Unlike the capillaries found in most tissues, the capillaries in the kidneys are fenestrated . These pores exclude relatively large substances like the cellular components of blood which remain in the blood capillaries. The basement membranes are a proteoglycan gel which has a large negative charge. The basement membrane can exclude most large molecules . Thus, blood plasma consists of ~7% protein while the glomerular filtrate is only about 0.03% protein. The last component of the filtration membrane is formed by the cells of the glomerular capsule. These podocytes extend pedicels that cover the capillaries. Between the pedicels are negatively charged filtration slits that exclude particles > 3nm. A healthy filtration membrane ensures that only water and very small solutes are filtered out of the blood....
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- Fall '10