Levels of protein structure

Levels of protein structure - Structure is important...

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Levels of protein structure Primary structure is the sequence of amino acids along the backbone. Secondary structure involves O or N of the peptide bond. Tertiary structure involves the amino acid side chains along the same backbone. Quaternary structure involves two or more protein chains. Structure is important because it is crucial to function. Why is our knowledge of protein structure relevant to health?
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Unformatted text preview: Structure is important because it is crucial to function. The substitution of Glu Val in hemoglobin causes sickle cell anemia, a disease which limits the ability of the tetrameric protein Hb to carry oxygen. The substitution is a chance in primary structure. The side chains of Glu and val differ considerably in their ability to bond; tertiary structure. A tetramer is composed...
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This note was uploaded on 01/27/2012 for the course BIOCHEM 212 taught by Professor Jeannestuckey during the Fall '11 term at University of Michigan.

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