Lecture 2 - EXAM II Fall term 2011 PROTEIN STRUCTURE AND...

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EXAM II Fall term 2011 PROTEIN STRUCTURE AND FUNCTION Professor Ruthann Nichols [email protected]; subject line BCHM 212 office hours, 2:30 – 4:30 pm, Fridays, 3340 MSRB III GSI, Nathan Raynard, [email protected] office hours, 3-5 pm, Exam II Lecture #2, W, Oct 12, 2011 Reading material, Chapter 18, pp. 570-585; Summary: Chapter Goals Problem Set 5 (posted on Ctools by M, Oct 17th ) Problem Set 5 is due Mon, Oct 31st at the beginning of Discussion
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Lecture 2 Goals 5. What types of interactions determine the overall shapes of proteins? Describe and recognize disulfide bonds, H bonds, and non-covalent interactions. 6. What are the secondary and tertiary structures of proteins? Define structures; describe α-helix and β-sheet; distinguish fibrous and globular proteins. 7. What is quaternary protein structure? Define quaternary structure; identify forces and give examples of quaternary structure. 8. What chemical properties do proteins have? Define hydrolysis and denaturation, give examples of agents which cause these events.
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18.8 Shape-Determining Interactions in Proteins Structure, required for function, is maintained by interactions along the protein backbone. H bonds form along the backbone when a H bonded to an electronegative atom is attracted to an unshared electron pair. The H in –NH and O in –C=0 meet these conditions. H bonds of R groups (side chains) connect different parts of a protein, near or far apart; atoms on the surface of a protein can H bond with surrounding water molecules. What is this type of structure? Secondary structure. What is this type of structure? Tertiary structure. What is the backbone? The primary structure; peptide bonds linking amino acids together.
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(salt bridges) result from positive and negative charges present in acidic and basic side chains. Hydrophobic interactions form between R groups from uneven distribution of electrons in a water-free, hydrophobic pocket. The large number of weak interactions are stabilizing.
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This note was uploaded on 01/27/2012 for the course BIOCHEM 212 taught by Professor Jeannestuckey during the Fall '11 term at University of Michigan.

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Lecture 2 - EXAM II Fall term 2011 PROTEIN STRUCTURE AND...

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