Lecture 1 - EXAM II Fall term 2011 PROTEIN STRUCTURE AND...

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EXAM II Fall term 2011 PROTEIN STRUCTURE AND FUNCTION Professor Ruthann Nichols nicholsr@umich.edu; subject line, BCHM 212 office hours, 2:30-4:30 pm, Fridays, 3340 MSRB III GSI, Nathan Raynard, nraynard@umich.edu office hours, 3-5 pm, Thursdays, 3340 MSRB III Exam II Lecture #1 Tu, Oct 11, 2011 Reading material, Chapter 18, pp. 552-569 Problem Set 4 (posted on CTools) Problem Set 4 is due Tues, Oct 25th at the beginning of Discussion
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Lecture 1 Goals 1. What are the structural features of amino acids? Describe and recognize amino acid structures and illustrate how they are connected. 2. What are the properties of amino acids? Describe the properties of amino acids and how their ionic charges vary with pH. 3. What is “handedness”? Why do amino acids have handedness? Explain what is responsible for handedness and recognize it in simple molecules. 4. What is protein primary structure? And, how is it illustrated? Define primary structure and how it is represented given its amino acid sequence. Why are we interested in amino acid structures? Amino acid properties? Amino acid handedness? Protein structure? Amino acid structures, properties, handedness & protein structure are critical for the body to function properly & for the scientist to develop diagnostic tests & design drugs.
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Proteins are involved in many functions including: structure - collagen in connective tissue, defense - immunoglobulins destroy foreign molecules, hormones - insulin facilitates use of glucose, contractility - myosin converts chemical energy to muscle movement, and catalysts - enzymes. 18.1 An Introduction to Biochemistry Biochemistry is the study of molecules in living organisms. Many professions utilize biochemistry from medicine to nutrition, law to industry. Biomolecules include proteins, carbohydrates, lipids, and nucleic acids. Biomolecules are polymers of repeating units. Proteins are polymers Despite its size, a protein is composed of the same functional groups (Table 18.1). It is important to know and understand the role of amino acid functional groups.
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Lecture 1 - EXAM II Fall term 2011 PROTEIN STRUCTURE AND...

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