I7 - Renal Physiology I Overview of Nephron Structure and...

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Renal Physiology I. Overview of Nephron Structure and Function A. General Nephron Structure 1. glomerulus - site of filtration from arterial blood 2. proximal convolute tubule- first tube off glomer. 3. Loop of Henle - U-turn connecting tubules 4. distal convoluted tubule - to the Collecting Tubule 5. collecting tubule - urine from many nephron 6. peritubular capillaries - "around" the "tubes" B. General Nephron Function 1. glomerular filtration 2. tubular reabsorption 3. tubular secretion C. Fluid Processing in the Kidneys 180 liters of blood fluid processes each day 1.5 liters of urine produced each day II. Glomerular Filtration A. Filtration Membrane 1. hydrostatic pressure - forces 1/5 of blood fluid through capillary' walls into glomerular capsule 2. filtration membrane - has three parts a. fenestrated capillary endothelium (prevents passage of blood cells) b. basal membrane (allows most solutes but larger proteins) c. visceral membrane of glomerular capsule 3. solutes that can pass into glomerular capsule
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