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II2 - Physiology of Blood II Erythrocytes(red blood ells...

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Physiology of Blood II. Erythrocytes (red blood ells; RBCs) A. Structure 1. 7.5 micron diameter; 2.0 micron thick 2. biconcave disk shape; ideal for gas exchange i. spectrin - elastic protein; allows shape change 3. mature cells are anucleate (no nucleus) 3. very few organelles; mainly a hemoglobin carrier i. hemoglobin – 33% of cell mass; carries oxygen 5. no mitochondria; only anaerobic respiration 6. ratio erythrocytes:leukocytes = 800:1 7. red blood cell count: # cells per cubic millimeter i. normal male count - 5.1 to 5.8 million ii. normal female count - 4.3 to 5.2 million B. Functions (oxygen & carbon dioxide transport) 1. hemoglobin - large molecules with globin and hemes a. globin - complex protein with 4 polypeptides (2 alpha and 2 beta polypeptides) b. heme group - IRON containing pigment part of hemoglobin to which oxygen binds i. each polypeptide has one heme group;each heme carries one O 2 c. normal hemoglobin levels (grams/l00 ml blood) i. infants 14-20 grams/l00 ml ii adult female 12-16 grams/100 ml iii adult male 13-18 grams/l00 ml 2. states of hemoglobin a.
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