III6 - III. Renal Physiology Tubular Reabsorption:...

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Renal Physiology III. Tubular Reabsorption: Reabsorbing the Glomerular Filtrate A. Overview of Reabsorption 1. filtrate - all fluid and its solutes pushed into the capsule 2. urine - filtrate minus reabsorbed substances + secreted substances 3. route of reabsorption (transepithelial process) luminal surface of tubule cells >> basolateral membrane of tubule cells >> interstitial fluid between tubule cells and capillaries >> endothelium of the peritubular capillary 4. most sugars and amino acids are reabsorbed 5. water and ion reabsorption depends on hormonal control B. Active Tubular Reabsorption 1. glucose, amino acids, lactate, vitamins, ions a. move across luminal surface by diffusion b. actively transported across basolateral membrane i. cotransported with Na+ c. diffuse into capillary by diffusion 2. transport maximum (Tm) when "carrier proteins" for specific solute becomes saturated and cannot carry the substance across the membrane a. diabetes mellitus - lower Tm (glucose lost) C. Passive Tubular Resorption
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This note was uploaded on 01/29/2012 for the course SCIE SYG2000 taught by Professor Bernhardt during the Fall '10 term at Broward College.

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III6 - III. Renal Physiology Tubular Reabsorption:...

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