III10 - III. Physiology of Blood Leukocytes (white blood...

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Physiology of Blood III. Leukocytes (white blood cells; WBCs) A. General Structure and Function 1. protection from microbes, parasites, toxins, cancer 2. 1% of blood volume; 4-11,000 per cubic mm blood 3. diapedesis - can "slip between" capillary wall 4. amoeboid motion - movement through the body 5. chemotaxis - moving in direction of a chemical 6. leukocytosis - increased "white blood cell count" in response to bacterial/viral infection 7. granulocytes - contain membrane-bound granules (neutrophils, eosinophils, basophils) 8. agranulocytes - NO membrane-bound granules (lymphocytes, monocytes) B. Granulocytes - granules in cytoplasm can be stained with Wright's Stain; bilobar nuclei; 10-14 micron diameter; all are phagocytic cells (engulf material) 1. neutrophils - destroy and ingest bacteria & fungi (polymorphonuclear leuks.; "polys") a. most numerous WBC b. c. defensins - antibiotic-like proteins (granules) d. polymorphonuclear - many-lobed nuclei
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III10 - III. Physiology of Blood Leukocytes (white blood...

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