VII6 - VII. Disorders of Hemostasis A. Thromboembolytic...

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VII. Disorders of Hemostasis A. Thromboembolytic Disorders (undesirable clotting) 1. thrombus - blood clot in normal blood vessel 2. embolus -blood clot/gas bubble floating in blood a. TPA, streptokinase - can dissolve a clot b. aspirin - inhibits Thromboxane formation c. d. dicumarol - anticoagulant, blocks Vitamin K B. Bleeding Disorders 1. thrombocytopenia - reduced platelet count; generally below 50,000 per cubic millimeter; can cause excessive bleeding from vascular injury 2. impaired liver function - lack of procoagulants (Clotting Factors) that are made in liver a. vitamin K - essential for liver to make Clotting Factors for coagulation 3. hemophilias - hereditary bleeding disorders that occur almost exclusively in males a. hemophilia A - defective Factor VIII (83%) b. hemophilia B - defective Factor IX (10%) c. Genentech. Inc. - now produces genetically engineered TPA and Factor VIII; patients do not need transfusions as often VIII. Blood Transfusions and Blood Typing
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This note was uploaded on 01/29/2012 for the course SCIE SYG2000 taught by Professor Bernhardt during the Fall '10 term at Broward College.

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VII6 - VII. Disorders of Hemostasis A. Thromboembolytic...

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