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Unformatted text preview: thrombin stimulates: fibrinogen -> fibrin (meshwork) Ca ++ & thrombin -> Factor XIII (fibrin stabilizer) B. Clot Retraction (shrinking of clot) 1. actomyosin - causes contraction of platelets 2. blood serum - plasma WITHOUT clotting Factors 3. platelet-derived growth factor (PDGF) - stimulates fibroblast migration and endothelial growth C. Clot Eradication (Fibrinolysis) 1. healing occurs over 2 - 10 days 2. tissue plasminogen activator (TPA) - causes the activation of plasminogen 3. plasminogen--> plasmin 4. plasmin degrades proteins within the clot D. Factors Limiting Growth and Formation of Clots 1. Limiting Normal Clot Growth a. blood moves too fast to allow procoagulants b. factors interfere with normal clotting i. prothrombin III - deactivates thrombin ii. protein C - inhibits clotting Factors iii. heparin - inhibits thrombin; prevents adherence of platelets to injured site...
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- Fall '10