VIII1 - 3. Bohr Effect - formation of Bicarbonate (through...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Physiology of Respiration VIII. Transport of Carbon Dioxide A. Dissolved in Blood Plasma (7-10%) B. Bound to Hemoglobin (20-30%) 1. carbaminohemoglobin - Carb Diox binds to an amino acid on the polypeptide chains 2. Haldane Effect - the less oxygenated blood is, the more Carb Diox it can carry a. tissues - as Ox is unloaded, affinity for Carb Diox increases b. lungs - as Ox is loaded, affinity for Carb Diox decreases, allowing it to be released C. Bicarbonate Ion Form in Plasma (60-70%) 1. Carbon Dioxide combines with water to form Bicarbonate CO 2 + H 2 O <==> H 2 CO 3 <==> H + + HCO 3 - 2. carbonic anhydrase - enzyme in RBCs that catalyzes this reaction in both directions a. tissues - catalyzes formation of Bicarbonate b. lungs - catalyzes formation of Carb Diox
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 3. Bohr Effect - formation of Bicarbonate (through Carbonic Acid) leads to LOWER pH (H+ increase), and more unloading of Ox to tissues a. since hemoglobin &quot;buffers&quot; to H + , the actual pH of blood does not change much 4. Chloride Shift - chloride ions move in opposite direction of the entering/leaving Bicarbonate, to prevent osmotic problems with RBCs D. Carbon Dioxide Effects on Blood pH 1. carbonic acid-bicarbonate buffer system low pH--&gt; HCO 3-binds to H + high pH--&gt; H 2 CO 3 releases H + 2. low shallow breaths--&gt; HIGH Carb Diox --&gt; LOW pH (higher H + ) 3. rapid deep breaths--&gt; LOW Carb Diox--&gt; HIGH pH (lower H + )...
View Full Document

This note was uploaded on 01/29/2012 for the course SCIE SYG2000 taught by Professor Bernhardt during the Fall '10 term at Broward College.

Ask a homework question - tutors are online