2009-Munoz_et_al - Single and joint-population analyses of...

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G. Muñoz, C. Ovilo, L. Silió, A. Tomás, J. L. Noguera and M. C. Rodríguez fatness and growth traits chromosome 6 and leptin receptor effects on Sus scrofa quantitative trait loci on Single- and joint-population analyses of two experimental pig crosses to confirm doi: 10.2527/jas.2008-1127 originally published online Oct 24, 2008; 2009.87:459-468. J Anim Sci http://jas.fass.org/cgi/content/full/87/2/459 the World Wide Web at: The online version of this article, along with updated information and services, is located on www.asas.org by on February 2, 2011. jas.fass.org Downloaded from
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ABSTRACT: The primary goal of this study was to detect and confirm QTL on SSC6 for growth and fat- ness traits in 2 experimental F 2 intercrosses: Iberian × Landrace (IB × LR) and Iberian × Meishan (IB × MS), which were used in this study for the first time in a QTL analysis related to productive traits. For this purpose, single- and joint-population analyses with sin- gle and bivariate trait models of both populations were performed. The presence of the SSC6 QTL for backfat thickness previously identified in the IB × LR cross was detected in this population with additional molecular information, but also was confirmed in the IB × MS cross. In addition, a QTL affecting BW was detected in both crosses in a similar position to the QTL detected for backfat thickness. This is the first study in which a QTL affecting BW is detected on SSC6 in the IB × LR cross, as well as in the IB × MS resource popula- tion. Furthermore, we analyzed a previously described nonsynonymous leptin receptor ( LEPR ) SNP located in exon 14 (c.2002C > T) for causality with respect to this QTL within both F 2 populations. Our results supported the previously reported association between LEPR alleles and backfat thickness in the IB × LR cross, and this association was also confirmed within the IB × MS cross. An association not reported before between LEPR alleles and BW was identified in both populations. Key words: backfat thickness, body weight, joint analysis, leptin receptor, pig, polymorphism ©2009 American Society of Animal Science. All rights reserved. J. Anim. Sci. 2009. 87:459–468 doi:10.2527/jas.2008-1127 INTRODUCTION Previous results obtained from several mapping populations have detected a highly significant QTL on SSC6 in the S0228 - Sw1881 interval that affects fatness and meat quality traits (Ovilo et al., 2005; Mohrmann et al., 2006; Edwards et al., 2008). Moreover, fine-map- ping and candidate gene analyses have suggested that a leptin receptor ( LEPR ) gene polymorphism could be responsible for the SSC6 QTL effects after a possible effect on food intake (Ovilo et al., 2005). Joint analy- sis of such data could lead to more power to increase precision of QTL location or could be used to confirm the presence of QTL detected in 1 population (Wall- ing et al., 2000; Kim et al., 2005; Pérez-Enciso et al., 2005). Nevertheless, joint analysis cannot be easily per- formed, because commonly different parental popula- tions, markers, environments, and phenotypic traits are analyzed in different studies. Identification of candidate
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2009-Munoz_et_al - Single and joint-population analyses of...

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