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2009-Ren_et_al - A genome scan for quantitative trait loci...

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Huang D. R. Ren, J. Ren, Y. Y. Xing, Y. M. Guo, Y. B. Wu, G. C. Yang, H. R. Mao and L.-S. Duroc x Chinese Erhualian resource population A genome scan for quantitative trait loci affecting male reproductive traits in a White doi: 10.2527/jas.2008-0923 originally published online Jul 3, 2008; 2009.87:17-23. J Anim Sci http://jas.fass.org/cgi/content/full/87/1/17 the World Wide Web at: The online version of this article, along with updated information and services, is located on www.asas.org by on October 22, 2010. jas.fass.org Downloaded from
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ABSTRACT: Chinese Erhualian boars have dramati- cally smaller testes, greater concentrations of circulat- ing androgens, and fewer Sertoli cells than Western commercial breeds. To identify QTL for boar reproduc- tive traits, testicular weight, epididymal weight, semi- niferous tubular diameter at 90 and 300 d, and serum testosterone concentration at 300 d were measured in 347 F 2 boars from a White Duroc × Chinese Erhual- ian cross. A whole genome scan was performed with 183 microsatellites covering 19 porcine chromosomes. A total of 16 QTL were identified on 9 chromosomes, in- cluding 1% genome-wide significant QTL for testicular weight at 90 and 300 d and seminiferous tubular diam- eter at 90 d on SSCX, and for epididymal weight and testosterone concentration at 300 d on SSC7. Two 5% genome-wide significant QTL were detected for testicu- lar weight at 300 d on SSC1 and seminiferous tubular diameter at 300 d on SSC16. Nine suggestive QTL were found on SSC1, 2, 3, 5, 7, 13, and 14. Chinese Erhual- ian alleles were not systematically favorable for greater reproductive performance. This study confirmed the previous significant QTL for testicular weight on SSCX and for epididymal weight on SSC7, and reported QTL for seminiferous tubular diameter and testosterone concentration at the first time. The observed different QTL for the same trait at different ages reflect the in- volvement of distinct genes in the development of male reproductive traits. Key words: boar, quantitative trait loci, reproductive trait ©2009 American Society of Animal Science. All rights reserved. J. Anim. Sci. 2009. 87:17–23 doi:10.2527/jas.2008-0923 INTRODUCTION The extensive implementation of AI in swine produc- tion requires selection on boars for reproductive traits. However, it is difficult to measure boar reproductive traits, and hence is difficult to estimate breeding value of boars. During recent years, considerable interest has been directed toward finding candidate genes affecting boar reproduction for marker-assisted selection (Chen et al., 2004; Nonneman et al., 2005; Wimmers et al., 2005). Unfortunately, candidate gene studies are often nonreproducible, and effects of candidate markers are sometimes population-specific (Georges, 2007). As an initial step to decipher genes underlying complex traits in farm animals, QTL mapping has been widely per- formed using experimental and commercial pedigrees.
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