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Unformatted text preview: L. A. Rempel, D. J. Nonneman, T. H. Wise, T. Erkens, L. J. Peelman and G. A. Rohrer traits in swine Association analyses of candidate single nucleotide polymorphisms on reproductive doi: 10.2527/jas.2009-1985 originally published online Sep 11, 2009; 2010.88:1-15. J Anim Sci http://jas.fass.org/cgi/content/full/88/1/1 the World Wide Web at: The online version of this article, along with updated information and services, is located on www.asas.org by on April 11, 2011. jas.fass.org Downloaded from ABSTRACT: The ability to identify young females with superior reproduction would have a large econom- ic impact on commercial swine production. Previous studies have discovered SNP associated with economi- cally important traits such as litter size, growth rate, and feed intake. The objective of this study was to test for association of candidate SNP with sow prolifi- cacy reproductive traits in gilts of a Landrace-Duroc- Yorkshire composite population. Association analyses regressed additive (A), dominant (D), and imprinting (I) SNP effects on each trait with an animal model. A carnitine palmitoyltransferase 1A SNP and a glycogen synthase 1 SNP were associated with age at puberty (AP; D = 10 d; P = 0. 0037 and A = 3.8 d; P = 0.0078, respectively). Four IGF2 SNP were associated with AP as well, having additive or dominant effects (3.2 to 5.8 d; P ≤ 0.0052). Two mannosidase 2B2 SNP and 2 pro- lactin receptor ( PRLR ) SNP were also associated with AP. Solute carrier 22, subfamily member 5 SNP was weakly associated with AP (D = 3.9 d; P < 0.10). Polymorphisms within glycogen synthase 1 and protein kinase AMP-activated, gamma 3 noncatalytic subunit had associations with ovulation rate. Estrogen receptor ( ESR ) 1, ESR2 , PPAR γ coactivator 1, and IGFBP3 SNP were significantly associated with weaning-to-es- trus interval. Two PRLR SNP were associated with total number of piglets born (A = 0.57 piglets; P = 0.0095 and D = 0.61 piglets; P = 0.0016, respectively). A SNP within PRLR was also associated with number of piglets born alive (D = 0.61; P = 0.0016). The PPAR γ coactivator 1 SNP was associated with total number of piglets born (D = 0.38 piglets; P = 0.0391) and num- ber of piglets born alive (D = 0.53 piglets; P = 0.0032). The SNP within ESR1 (A = 0.65 piglets; P = 0.0950), ESR2 (A = −0.33 piglets; P = 0.0176), IGF2 SNP (A = −0.26 piglets; P = 0.0032), and IGFBP3 SNP (D = 0.35 piglets; P = 0.0683) were associated with num- ber of piglets born dead. A leptin SNP was associated with mummified fetuses (D = 0.09 piglets; P = 0.0978). Many of the SNP analyzed in this study are from genes involved in regulation of metabolism, suggesting that there is an important link between physiological events associated with reproduction and energy utilization....
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This note was uploaded on 01/26/2012 for the course ECON 2272 taught by Professor Gay during the Spring '08 term at Birmingham-Southern College.
- Spring '08