2010-Sironen_et_al - A. I. Sironen, P. Uimari, T. Serenius,...

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Unformatted text preview: A. I. Sironen, P. Uimari, T. Serenius, B. Mote, M. Rothschild and J. Vilkki populations Effect of polymorphisms in candidate genes on reproduction traits in Finnish pig doi: 10.2527/jas.2009-2426 originally published online Nov 20, 2009; 2010.88:821-827. J Anim Sci http://jas.fass.org/cgi/content/full/88/3/821 the World Wide Web at: The online version of this article, along with updated information and services, is located on www.asas.org by on March 5, 2011. jas.fass.org Downloaded from ABSTRACT: Reproduction traits play an important role in economically viable piglet production and are closely related to the quality and length of the produc- tive life of the sow. A increased removal rate of young sows is undesirable not only because of the associ- ated financial penalties incurred, but also because of ethical concerns. Candidate genes and gene pathways have been identified for fertility in model species, and recent studies have provided evidence that polymor- phisms within these genes are associated with repro- duction traits in American Yorkshire/Large White and Landrace populations. In this study we evaluated the impact of single polymorphisms (n = 7) in 7 candi- date genes on reproductive efficiency in Finnish York- shire (n = 280) and Landrace (n = 271) populations: IGFBP1 , IGFBP2 , IGFBP3 , IGFBP5 , CPTIA (carni- tine O-palmitoyltransferase I), COX2 (PG-endoperox- ide synthase 2, also known as cyclooxgenase-2), and SLC22A5 [organic cation/carnitine transporter 2 (sol- ute carrier family member I), OCTN2 ]. In the Finnish Yorkshire population, only 4 of the analyzed markers were polymorphic. Significant effects on farrowing time were detected from the Yorkshire data, with polymor- phisms within the genes CPT1A [a (allele substitution effect of allele A) = 2.97 d for age at first farrowing)], IGFBP3 (a = 0.54 d for farrowing interval of parities >1), and IGFBP5 (a = 3.22, 1.27, and 0.85 d for age at first farrowing and farrowing interval in the first and later parities, respectively). For the Landrace popula- tion, 6 markers were polymorphic, and significant ef- fects were detected for traits affecting litter size. The polymorphism within the COX2 gene had an additive effect of 0.3 piglets for litter size in parities >1, and the IGFBP1 gene had an additive effect of 0.21, 0.26, and 0.11 piglets for litter size in the first parity, pari- ties >1, and stillborn in parities >1, respectively. The additive effect of the SNP within the IGFBP2 gene was 0.16, 0.09, and 0.09 piglets for litter size in parities >1 and stillborn in the first and later parities, respec- tively. Finally, the IGFBP5 gene had an additive effect of 0.18, 0.07, and 0.07 piglets for litter size in the first parity, stillborn in parities >1, and mortality between farrowing and weaning in the first parity, respectively....
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This note was uploaded on 01/26/2012 for the course ECON 2272 taught by Professor Gay during the Spring '08 term at Birmingham-Southern College.

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2010-Sironen_et_al - A. I. Sironen, P. Uimari, T. Serenius,...

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