lecture 24 - MCB 354 Lecture 2 Metabolism, Bioenergetics...

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MCB 354 Lecture 2 Metabolism, Bioenergetics continued Reading in Lehninger : Introduction to Part II Chapter 13
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2-1 FREE ENERGIES ARE ADDITIVE THE MECHANISM OF THE SUM NEED NOT BE THOSE OF THE PARTIAL RXNS
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ATP LINKED METABOLISM PROVIDES ENERGY BY GROUP TRANSFER: COVALENT COUPLING TO UTILIZE FREE ENERGY 2-2 - Contribution of ATP often written as a single step - But is almost always a 2-step process in which part of the ATP molecule (phosphoryl group, pyrophosphoryl group, or AMP) is - first transferred to either a substrate molecule or to a functional group in an enzyme, becoming covalently linked and raising its free energy content - second , the phosphate-containing moiety is displaced, generating Pi, PPi, or AMP - ATP participates covalently in the enzyme-catalyzed reaction to which it contributes free energy
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RELATIVE ENERGIES OF IMPORTANT PHOSPHATE COMPOUNDS: ATP CAN BE MADE FROM HIGHER ENERGY PHOSPHATES ATP CAN BE USED AS A PHOSPHORYL GROUP DONOR ATP CAN BE USED TO DRIVE UNFAVORABLE REACTIONS 2-3
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2-4
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NUCLEOPHILIC ATTACK BY WATER OR -OH GROUP CAN OCCUR AT ANY OF THE THREE PHOSPHATES IN ADENYLATION PPi HYDROLYSIS FURTHER PULLS EQUILIBRIUM 2-5
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IN ADENYLATION, PPi HYDROLYSIS FURTHER PULLS EQUILIBRIUM WE WILL SEE THIS IN FATTY ACID METABOLISM 2-6
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lecture 24 - MCB 354 Lecture 2 Metabolism, Bioenergetics...

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