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lecture 25 - MCB 354 Lecture 3 Glycolysis Part I Reading in...

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MCB 354 Lecture 3 Glycolysis, Part I Reading in Lehninger : Chapter 14
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GLYCOLYSIS: THE EMBDEN-MEYERHOF PATHWAY (1940s) Glykys + Lysis : “sweet splitting” 6-CARBON TWO 3-CARBON COMPLETE OXIDATION ALSO USES THE TCA CYCLE & OX-PHOS OVERALL: SIX CARBONS OF THE REDUCED ORGANIC SUBSTRATE GLUCOSE ARE CONVERTED TO WATER AND CARBON DIOXIDE THE OVERALL GOAL IS TO TRAP THE ENERGY RELEASED IN THESE OXIDATIONS IN A FORM OF CHEMICAL ENERGY THAT CAN BE USED LATER BY THE ORGANISM THE ENERGY CURRENCIES ARE: ATP, NADH AND ACETYL-CoA ANAEROBIC OXIDATION YIELDS LESS ENERGY TRAPPED IN A USEFUL FORM 3-1
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WHY GLUCOSE? 3-2 GLUCOSE IS FORMED FROM FORMALDEHYDE UNDER PREBIOTIC CONDITIONS MOST STABLE HEXOSE: SUBSTITUENTS AXIAL IN PYRANOSE LOW POTENTIAL FOR NON-ENZYMATIC PROTEIN GLYCOSYLATION EXISTS AN UNREACTIVE PYRANOSE (HEMIACETAL) WHEN THE OPEN FORM OF THE SUGAR IS NEEDED, ENZYMES WILL OPEN THE RING SYSTEM)
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GLYCOLYSIS HAS TWO PHASES PREPARATORY PHASE: ENERGY IS USED 3-3
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GLYCOLYSIS HAS TWO PHASES PAYOFF PHASE: ENERGY IS GENERATED 3-4
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STEP #1: GLUCOSE -> GLUCOSE 6-PHOSPHATE PHOSPHORYL GROUP TRANSFER PHOSPHORYL GROUPS ACT AS “HANDLES” FOR MOLECULAR
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