lecture 27 - MCB 354 Lecture 5 Other Carbohydrates...

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Unformatted text preview: MCB 354 Lecture 5 Other Carbohydrates Gluconeogenesis Reading in Lehninger : Chapter 14 MOST FRUCTOSE IS METABOLIZED IN THE LIVER INITIATED BY FRUCTOKINASE N.B. HIGH GLUCOSE CONCENTRATION IN THE LIVER PREVENTS MUCH DIRECT PHOSPHORYLATION OF FRUCTOSE TO MAKE FRUCTOSE-6-P BY HEXOKINASE INPUT OF FRUCTOSE THINK HOW THIS ENZYME MIGHT WORK 5-1 INPUT OF GALACTOSE GLYCOLYSIS AS FROM GLYCOGEN BREAKDOWN CHANGE STEREO- CHEMISTRY AROUND C-4 5-2 GALACTOSE FEEDPOINT: STEP #1 5-3 GALACTOSE FEEDPOINT: STEP #2 WHY WOULD IT WANT TO DO THIS REACTION WITH THE UDP-SUGAR? REGULATION O OH OH NH N O O uridine 5-4 MECHANISM: UDP GALACTOSE EPIMERASE HOW CAN THIS WORK? COULD PULL THE ALCOHOL PROTON - BUT THEN? COULD ONE MAKE AN ENE-INTERMEDIATE SOMEHOW AND RE-PROTONATE? HOW ABOUT DEHYDRATION - REHYDRATION? LABEL WATER? WHAT IF YOU KNEW THAT THE ENZYME HAS NAD+ TIGHTLY BOUND? 5-5 5-6 5-7 LACTOSE INTOLERANCE DEFICIENCY IN LACTASE LACTOBACILLI IN THE GUT CONVERT LACTOSE TO LACTIC ACID GENERATING METHANE AND HYDROGEN GAS 5-8 GLUCONEOGENESIS LEHNINGER 14.4 p.551 ff....
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This note was uploaded on 01/29/2012 for the course MCB 354 taught by Professor Spees during the Spring '09 term at University of Illinois, Urbana Champaign.

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lecture 27 - MCB 354 Lecture 5 Other Carbohydrates...

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