lecture 28 - MCB 354 Lecture 6 Regulation of Carbohydrate...

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MCB 354 Lecture 6 Regulation of Carbohydrate Metabolism Pentose Phosphate Pathway Reading in Lehninger : Chapters 14 and 15
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RECIPROCAL REGULATION OF GLYCOLYSIS AND GLUCONEOGENESIS GOAL: PREVENT FUTILE CYCLING RATHER THAN MEMORIZE, ASK - DOES IT MAKE SENSE? e.g. IF THE CELL NEEDS ENERGY, GLYCOLYSIS SHOULD BE STIMULATED. F-2,6-BP IS A STRONG REGULATOR OF LIVER BISPHOSPHATASE AND PFK. F-2,6-BP IS HIGH IN THE FED STATE AND LOW IN STARVATION. LEHNINGER 15.3 6-1
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A CRITICAL POINT OF REGULATION OF GLYCOLYSIS / GLUCONEOGENESIS PHOSPHOFRUCTOKINASE COOPERATIVE TETRAMER ATP BINDS TO REGULATORY SITES IN ADDITION, AMP IS A COMPETITIVE INHIBITOR OF ATP BINDING RESPONDS TO ENERGY CHARGE 6-2
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REGULATION POINTS OF GLYCOLYSIS PHOSPHOFRUCTOKINASE PFK IS INHIBITED BY CITRATE LINKS TCA CYCLE AND THE AVAILABILITY OF CARBON FOR BIOSYNTHESIS PFK IS ACTIVATED BY FRUCTOSE 2,6 BISPHOSPHATE INCREASES AFFINITY FOR F-6-P LEHNINGER P.587 6-3
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IS A KINASE (PFK-2) AS WELL AS A PHOSPHATASE. THERE ARE FIVE HUMAN
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This note was uploaded on 01/29/2012 for the course MCB 354 taught by Professor Spees during the Spring '09 term at University of Illinois, Urbana Champaign.

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lecture 28 - MCB 354 Lecture 6 Regulation of Carbohydrate...

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