lecture 30 - MCB 354 Lecture 8 Tricarboxylic Acid Cycle,...

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Unformatted text preview: MCB 354 Lecture 8 Tricarboxylic Acid Cycle, Part II Reading in Lehninger : Chapter 16 2: ISOMERIZATION BY REVERSIBLE HYDRATION/ DEHYDRATION ACONITASE UPHILL ( G = + 3.2 kcal/mole) 8-1 ACONITASE: OUR FIRST EXAMPLE OF AN IRON-SULFUR PROTEIN 8-2 3: OXIDATIVE DECARBOXYLATION ISOCITRATE DEHYDROGENASE NOTE TWO FORMS: NADH UTILIZING (MITOCHONDRIA) AND NADPH UTILIZING (CYTOSOL AND MITOCHONDRIA) THE SAME ELECTRON SINK THING AGAIN: A -KETO ACID SET UP FOR DECARBOXYLATION JUST LIKE 6-PHOSPHOGLUCONATE DEHYDROGENASE ANOTHER EXAMPLE OF AN ACTIVE SITE METAL STABILIZING -VE CHARGE 8-3 4: OXIDATIVE DECARBOXYLATION KETOGLUARATE DEHYDROGENASE COMPLEX THE REACTION IS ANALOGOUS AND HOMOLOGOUS TO PYRUVATE DECARBOXYLATION DECARBOXYLATION OF AN -KETO ACID DRIVES FORMATION OF HIGH ENERGY COMPOUND 8-4 5: PHOSPHORYL GROUP TRANSFER: TRAPPING THE THIOESTER ENERGY SUCCINYL-CoA SYNTHASE OR SUCCINATE THIOKINASE CoA IS REGENERATED 8-5 SUCCINYL-CoA SYNTHASE, SUCCINATE THIOKINASE REACTION INVOLVES A PHOSPHO-HISTIDINE INTERMEDIATE...
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This note was uploaded on 01/29/2012 for the course MCB 354 taught by Professor Spees during the Spring '09 term at University of Illinois, Urbana Champaign.

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lecture 30 - MCB 354 Lecture 8 Tricarboxylic Acid Cycle,...

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