lecture 31___9 - MCB 354 Lecture 9 Fatty Acid Catabolism,...

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Unformatted text preview: MCB 354 Lecture 9 Fatty Acid Catabolism, Part I Reading in Lehninger : Chapter 17 THE MITOCHONDRION ENZYMES OF THE OX-PHOS CHAIN AND TCA CYCLE ARE FOUND IN THE MITOCHONDRIA 1 ELECTRONS -> PROTON MOTIVE FORCE -> ATP TCA OX-PHOS +- 9-1 ANOTHER PICTURE SHOWING ENZYME LOCALIZATION 9-2 THE TCA CYCLE OCCURS IN MITOCHONDRIA. OF LEHNINGER FAME 9-3 THE TCA CYCLE OCCURS IN MITOCHONDRIA. OF LEHNINGER FAME 9-4 GLYCOLYSIS AND TCA CYCLE: ENERGY (ATP) BALANCE 1 NADH = 2.5 ATP (Ox Phos) 1 FADH2 = 1.5 ATP (Ox Phos) GLUCOSE (C6) -> 32 ATP (5.3 / C) 9-5 Fatty acids 1. Carboxylic acids with long hydrocarbon chains 2. Chain can be fully saturated , or contain one or more double bonds (a few have 3-C rings,-OH groups, or methyl group branches) 3. Nomenclature: specifies chain length and # double bonds, separated by colon: eg. 16-C saturated palmitic acid = 16:0 18-C oleic acid (w. one double bond = 18:1) Position of double bond specified by superscript #s following (e.g. 20-C FA with double bonds between C-9 & C-10 and between C-12 and C-13 = 20:2 ( 9,12) 4. The most commonly occurring FA have even #s of carbons in unbranched chains (even # results from biosynthesis from C2 units) 5. FA are rarely free in nature: usually ester- or amide-linked to other components of lipids (in vertebrates, free FA circulate in blood bound non-covalently to a carrier protein, serum albumin) 18:0 9-6 Triacylglycerols- 3 FA ester-linked to glycerol- Ester linkage is susceptible to alkaline hydrolysis (saponification)- FA can vary 9-7 Unsaturated fatty acids Double bond introduces rigid 30 bend 18:3 ( 9,12,15) Generalizations : 1. In monounsaturated FA, double bond is usually between C-9 and C-10 (...
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lecture 31___9 - MCB 354 Lecture 9 Fatty Acid Catabolism,...

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