lecture 32___10 - MCB 354 Lecture 10 Fatty Acid Catabolism,...

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MCB 354 Lecture 10 Fatty Acid Catabolism, Part II Reading in Lehninger : Chapter 17
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… THE REACTION IS SEQUENTIALLY REPEATED OVERALL REACTION FOR PALMITATE PALMITOYL-CoA + 7 CoA + 7 FAD + 7 NAD+ + 7 H20 ----> 8 ACETYL-CoA + 7 FADH2 + 7 NADH + 7 H+ ATP SYNTHESIS: ~ 2.5 ATP/NADH + ~ 1.5 ATP/FADH2 + 10 ATP/ACETYL CoA (TCA) = 108 PALMITOYL-CoA + 23 O2 + 108 Pi + 108 ADP ----> CoA + 108 ATP + 16 CO2 + 23 H2O THE CAMEL GETS ITS WATER! 10-1
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OXIDATION OF UNSATURATED FATTY ACIDS: SINGLE DOUBLE BOND THE cis DOUBLE BONDS CANNOT BE METABOLIZED NORMAL β OXIDATION PROCEEDS UNTIL THE cis- 3 BOND IS ENCOUNTERED ENOYL CoA ISOMERASE CONVERTS THE cis- 3 BOND TO trans- 2 THIS IS A NORMAL INTERMEDIATE IN β OXIDATION AND METABOLISM PROCEEDS 10-2
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OXIDATION OF POLY UNSATURATED FATTY ACIDS NORMAL β OXIDATION PROCEEDS UNTIL THE cis- 3 BOND IS ENCOUNTERED THE ISOMERASE ACTS AS BEFORE ONE MORE ROUND OF β OXIDATION GENERATES A cis- 4 BOND 10-3
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OXIDATION OF POLY UNSATURATED FATTY ACIDS - 2 A PROBLEM OCCURS WHEN ACYL CoA DEHYDROGENASES ACTS ON THIS INTERMEDIATE DIENOYL CoA IS NOT A SUBSTRATE FOR THE HYDRATASE 10-4
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OXIDATION OF POLY UNSATURATED FATTY ACIDS - 3 A REDUCTASE IS USED TO REDUCE THE UNWANTED DOUBLE BOND ISOMERIZATION FOLLOWS AS BEFORE 10-5
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POLYUNSATURATED FATTY ACID OXIDATION: THE TEXTBOOK FIGURE 10-6
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OXIDATION OF POLY UNSATURATED FATTY ACIDS - SUMMARY THE TWO NEW ENZYMES REQUIRED ARE SHOWN IN YELLOW 10-7
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lecture 32___10 - MCB 354 Lecture 10 Fatty Acid Catabolism,...

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