lecture 33___11 - MCB 354 Lecture 11 Amino Acid Catabolism...

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MCB 354 Lecture 11 Amino Acid Catabolism Urea Cycle Reading in Lehninger : Chapter 18
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AMINO ACID CATABOLISM LEHNINGER CHAPTER 18 AFTER A MEAL, CARNIVORES CAN GET ~ 90% OF THEIR ENERGY FROM AMINO ACID OXIDATION THREE METABOLIC CONDITIONS WHEN AMINO ACIDS ARE BEING OXIDIZED: 1. DURING NORMAL AA TURNOVER 2. AFTER RICH PROTEIN MEAL AND WHEN THERE IS LITTLE PROTEIN SYNTHESIS 3. STARVATION OR DIABETES WHEN CHO ARE NOT BEING METABOLIZED FOCUS IS ON THE FATE OF NITROGEN 11-1
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AA BREAKDOWN SEPARATES NITROGEN FROM THE CARBON SKELETON THE FATE OF THE AMINO GROUP LINKS TCA AND UREA CYCLE IN HUMAN PROTEIN METABOLISM AND THE MAINTENANCE OF NITROGEN HOMEOSTASIS 11-2
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DEGRADATION OF AMINO ACIDS IN THE LIVER BEGINS WITH THE REMOVAL OF THE AMINO GROUP AMINOTRANSFERASE CONVERT AMINOACID TO KETOACID 11-3
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DEGRADATION OF AMINO ACIDS IN THE LIVER BEGINS WITH THE REMOVAL OF THE AMINO GROUP REMOVAL OF THE AMINO ACID AMINO GROUP IS A TRANSAMINATION AMINO GROUPS ARE COLLECTED IN A GLUTAMATE POOL 11-4
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DIETARY PROTEIN IS ENZYMATICALLY DEGRADED TO AMINO ACIDS NEUTRALIZATION OF STOMACH ACID RELEASE OF PANCREATIC PROTEASES 11-6
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TRANSAMINASES (AMINOTRANSFERASES) PYRIDOXAL PHOSPHATE COFACTOR (DERIVED FROM VITAMIN B6 - PYRIDOXINE) 11-7
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PYRIDOXAL IS A VERSATILE COFACTOR AMINO TRANSFERASES DECARBOXYLASES VERY FEW: e.g. CYSTATHIONASE AN AMINO ACID SCHIFF-BASE LINKAGE WITH PLP HAS MANY FATES 11-8
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(2) THE PLP COFACTOR FORMS A SCHIFF’S BASE (ALDIMINE) TO THE ε GROUP OF LYS THE “ELECTRON PUSHING” FOR SCHIFF BASE FORMATION IS AS DESCRIBED BEFORE FOR ALDOLASE (FIG 14-5 LEHNINGER). THE AMINO GROUP
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This note was uploaded on 01/29/2012 for the course MCB 354 taught by Professor Spees during the Spring '09 term at University of Illinois, Urbana Champaign.

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lecture 33___11 - MCB 354 Lecture 11 Amino Acid Catabolism...

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