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lecture 34___12 - MCB 354 Lecture 12 Oxidative...

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MCB 354 Lecture 12 Oxidative Phosphorylation Reading in Lehninger : Chapter 19
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OXIDATIVE PHOSPHORYLATION LEHNINGER CHAPTER 19 PP. 707-722 OVERVIEW: REDUCED PYRIDINE NUCLEOTIDES AND SUCCINATE FROM GLYCOLYSIS / TCA CYCLE GENERATE ENERGY THROUGH ELECTRON TRANSFER COUPLED PROTON TRANSLOCATION IN THE REDUCTION OF ATMOSPHERIC DIOXYGEN TO WATER THESE WILL ACCOUNT FOR 26 / 30 ATPs GENERATED FROM GLUCOSE METABOLISM WE DO NOT COVER PHOTOPHOSPHORYLATION 12-1
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THE MITOCHONDRION ENZYMES OF THE OX-PHOS CHAIN AND TCA CYCLE ARE FOUND IN THE MITOCHONDRIA 1 μ ELECTRONS -> PROTON MOTIVE FORCE -> ATP TCA OX-PHOS + - 12-2
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ANOTHER PICTURE SHOWING ENZYME LOCALIZATION 12-3
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THE MAJOR SOURCE OF ELECTRONS FOR OX-PHOS ARE NADH AND FADH2 OTHER DEHYDROGENASES EXIST THAT CAN COUPLE INTO OX-PHOS 1.14 V ENERGY FROM NADH DRIVES OXYGEN REDUCTION TO WATER HOMEWORK: CALCULATE Go’ FOR THIS COUPLE 12-4
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IN METABOLISM WE SAW HOW ENZYMES CONTROLLED PROTON TRANSFER EVENTS IN OX-PHOS WE ARE DEALING WITH ELECTRON TRANSFER PROCESSES COMMON PROSTHETIC GROUPS INVOLVED IN ET PROCESSES: FLAVOPROTEINS - FAD OR FMN CYTOCHROMES - IRON PORPHYRINS - HEME COPPER IONS IRON - SULFUR PROTEINS CENTRAL ELECTRON CARRIERS IN THE MEMBRANE: QUINONES 12-5
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FLAVOPROTEINS TWO ELECTRON CARRIERS, CYCLE THROUGH A SEMIQUINONE STATE THERE ARE TWO COUPLED PROTONATION EVENTS THERE IS A REDOX POTENTIAL ASSOCIATED WITH EACH ET REACTION 12-6
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CYTOCHROMES IRON HETEROCYLES: “NORMALLY” ONE ELECTRON CARRIERS Lipophilic chain Covalently attached to protein Note propionic acid groups 12-7
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