lecture 34___12 - MCB 354 Lecture 12 Oxidative...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: MCB 354 Lecture 12 Oxidative Phosphorylation Reading in Lehninger : Chapter 19 OXIDATIVE PHOSPHORYLATION LEHNINGER CHAPTER 19 PP. 707-722 OVERVIEW: REDUCED PYRIDINE NUCLEOTIDES AND SUCCINATE FROM GLYCOLYSIS / TCA CYCLE GENERATE ENERGY THROUGH ELECTRON TRANSFER COUPLED PROTON TRANSLOCATION IN THE REDUCTION OF ATMOSPHERIC DIOXYGEN TO WATER THESE WILL ACCOUNT FOR 26 / 30 ATPs GENERATED FROM GLUCOSE METABOLISM WE DO NOT COVER PHOTOPHOSPHORYLATION 12-1 THE MITOCHONDRION ENZYMES OF THE OX-PHOS CHAIN AND TCA CYCLE ARE FOUND IN THE MITOCHONDRIA 1 ELECTRONS -> PROTON MOTIVE FORCE -> ATP TCA OX-PHOS +- 12-2 ANOTHER PICTURE SHOWING ENZYME LOCALIZATION 12-3 THE MAJOR SOURCE OF ELECTRONS FOR OX-PHOS ARE NADH AND FADH2 OTHER DEHYDROGENASES EXIST THAT CAN COUPLE INTO OX-PHOS 1.14 V ENERGY FROM NADH DRIVES OXYGEN REDUCTION TO WATER HOMEWORK: CALCULATE Go FOR THIS COUPLE 12-4 IN METABOLISM WE SAW HOW ENZYMES CONTROLLED PROTON TRANSFER EVENTS IN OX-PHOS WE ARE DEALING WITH ELECTRON TRANSFER PROCESSES COMMON PROSTHETIC GROUPS INVOLVED IN ET PROCESSES: FLAVOPROTEINS - FAD OR FMN CYTOCHROMES - IRON PORPHYRINS - HEME COPPER IONS IRON - SULFUR PROTEINS CENTRAL ELECTRON CARRIERS IN THE MEMBRANE: QUINONES 12-5 FLAVOPROTEINS TWO ELECTRON CARRIERS, CYCLE THROUGH A SEMIQUINONE STATE THERE ARE TWO COUPLED PROTONATION EVENTS THERE IS A REDOX POTENTIAL ASSOCIATED WITH EACH ET REACTION 12-6 CYTOCHROMES IRON HETEROCYLES: NORMALLY ONE ELECTRON CARRIERS Lipophilic chain Covalently attached to protein Note propionic acid groups 12-7 IRON SULFUR PROTEINS...
View Full Document

Page1 / 29

lecture 34___12 - MCB 354 Lecture 12 Oxidative...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online