lecture 35___13 - MCB 354 Lecture 13 ATP Synthase Reading...

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Unformatted text preview: MCB 354 Lecture 13 ATP Synthase Reading in Lehninger : Chapter 19 The chemiosmotic hypothesis The free energy of electron transport is conserved by pumping protons from the mitochondrial matrix to the intermembrane space so as to create an electrochemical H + gradient across the inner mitochondrial membrane. The electrochemical potential of this gradient is harnessed to synthesize ATP . Peter Mitchell 13-1 THE ATP SYNTHASE (ATPase) HOW DOES IT WORK? FIRST LOOK AT STRUCTURES 13-2 THE ATP SYNTHASE (ATPase) F-TYPE TRANSPORTERS OXIDATIVE PHOSPHORYLATION F1 “BALL” ~ 8.5 nm FO “STICK” SOMETIMES CALLED “SUBUNITS” COMPLEX V N.B. THE “1” WAS BECAUSE IT WAS THE FIRST FACTOR IDENTIFIED AS ESSENTIAL FOR OX-PHOS, THE “Oh” AS THE OLIGOMYCIN SENSITIVE SITE. “ase” WAS USED SINCE ISOLATED F1 FRAGMENTS HYDROLYZED ATP. 13-3 AN IMPORTANT EXPERIMENT REVEALS THE ROLE OF THE PROTON GRADIENT F1 IS INCUBATED WITH ATP AND LABELED WATER F1 CATALYZES REVERSIBLE PHOSPHORYLATION THE EQUILIBRIUM CONSTANT IS NEAR 1!...
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This note was uploaded on 01/29/2012 for the course MCB 354 taught by Professor Spees during the Spring '09 term at University of Illinois, Urbana Champaign.

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lecture 35___13 - MCB 354 Lecture 13 ATP Synthase Reading...

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