lecture 36___14 - MCB 354 Lecture 14 Fatty Acid...

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MCB 354 Lecture 14 Fatty Acid Biosynthesis Reading in Lehninger : Chapter 21
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1. PRINCIPAL FORM OF STORED ENERGY 2. PIGMENTS (RETINAL) 3. COFACTORS (VITAMIN K) 4. DETERGENTS (BILE) 5. HORMONES (VITAMIN D, STEROIDS) 6. MESSENGERS (EICOSANOIDS, PI) 7. MEMBRANE PROTEIN ANCHORS (PRENYL GROUPS) BIOSYNTHESIS IS ENDERGONIC AND REDUCTIVE USES ATP AND NADPH LEHNINGER CHAPTER 21 BIOLOGICAL ROLES: 14-1
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FATTY ACID BIOSYNTHESIS VERSES CATABOLISM LOCATION CYTOSOL MITOCHONDRIA SYNTHESIS OXIDATION -SH CARRIER ACP CoA ENZYMES LARGE COMPLEX MOSTLY INDIVIDUAL REDOX FACTOR NADPH NAD+, FAD 14-2
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FATTY ACID SYNTHESIS MALONYL CoA IS THE TWO CARBON DONOR MADE BY THE HIGHLY REGULATED AND FIRST COMMITTED STEP IN BIOSYNTHESIS ACETYL CoA CARBOXYLASE THE COFACTOR BIOTIN IS LINKED TO A LYS RESIDUE OF THE BIOTIN CARRIER PROTEIN RECALL PROPIONYL CoA CARBOXYLASE, PYRUVATE CARBOXYLASE 14-3
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… ALL ATTACHED TO A MULTI-FUNCTIONAL ENZYME COMPLEX: 14-4
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ACETYL CoA CARBOXYLASE (ACC-1) IN HUMANS, A LARGE (265 kD) THREE ACTIVE SITE ENZYME HIGHLY REGULATED BY PHOSPHORYLATION 14-5
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SUBSEQUENT REACTIONS: THE FATTY ACID SYNTHASE COMPLEX HUMAN: 7+ ENZYMATIC ACTIVITIES IN A LARGE DIMER OF 240 kD PROTEINS 14-6
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THE SEPARATE POLYPEPTIDES IN E. coli PROVIDE A ROAD MAP FOR FUNCTIONAL UNDERSTANDING 14-7
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OVERVIEW: TWO -SH TETHERING SITES ON THE ENZYME 14-8 ACP
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OVERVIEW: 14-9
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This note was uploaded on 01/29/2012 for the course MCB 354 taught by Professor Spees during the Spring '09 term at University of Illinois, Urbana Champaign.

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lecture 36___14 - MCB 354 Lecture 14 Fatty Acid...

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