lecture 37___15 - MCB 354 Lecture 15 Sterols Eicosanoids...

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MCB 354 Lecture 15 Sterols Eicosanoids Reading in Lehninger : Chapter 21
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CHOLESTEROL AND STEROID HORMONE BIOSYNTHESIS 1. PRINCIPAL FORM OF STORED ENERGY 2. PIGMENTS (RETINAL) 3. COFACTORS (VITAMIN K) 4. DETERGENTS (BILE) 5. HORMONES (VITAMIN D, STEROIDS) 6. MESSENGERS (EICOSANOIDS, PI) 7. MEMBRANE PROTEIN ANCHORS (PRENYL GROUPS) BIOSYNTHESIS IS ENDERGONIC AND REDUCTIVE USES ATP AND NADPH LEHNINGER CHAPTER 21.4 PP 831-845 FATTY ACID & LIPID BIOSYNTHESIS (III): CHOLESTEROL
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THE CARBONS OF CHOLESTEROL COME FROM ACETATE HO HO CH CH 3 H H H CH CH 3 CH CH 3 CH CH 3 CH CH 3 THE CHOLESTEROL NUCLEUS
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CHOLESTEROL BIOSYNTHESIS: OVERVIEW ACETATE CONDENSATION FORMING MEVALONATE CONVERSION TO “ACTIVATED ISOPRENE” SIX 5-CARBON ISOPRENES ARE CONDENSED TO FORM SQUALENE CYCLIZATION OF SQUALENE TO FORM CHOLESTEROL NOTE: ~27 CARBONS NOT MULTIPLE OF 5!
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CHOLESTEROL BIOSYNTHESIS: STEP #1 - MEVALONATE HMG-CoA REDUCTASE IS THE TARGET OF THE STATINS ACETYL-CoA CONDENSATION- REPRISE - FATTY ACID CATABOLISM INTEGRAL MEMBRANE PROTEIN OF THE SMOOTH ER
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CHOLESTEROL BIOSYNTHESIS: STEP #2 - ACTIVATED ISOPRENE It’s the leaving group thing again!
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This note was uploaded on 01/29/2012 for the course MCB 354 taught by Professor Spees during the Spring '09 term at University of Illinois, Urbana Champaign.

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lecture 37___15 - MCB 354 Lecture 15 Sterols Eicosanoids...

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