lecture 39___17 - MCB 354 Lecture 17 Nucleotide...

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MCB 354 Lecture 17 Nucleotide Biosynthesis Reading in Lehninger : Chapter 22
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Go’= - 7.3 kcal/mol Go’= - 10.9 kcal/mol ACTUAL FREE ENERGY DEPENDS ON Mg CONCENTRATION SOLVATION ELECTROSTATICS RESONANCE THE ATP CURRENCY THE “HIGH ENERGY BOND” IS A MISNOMER 17-1
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17-2
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17-3
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SYNTHESES OF PURINE NUCLEOTIDES 17-4
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THE PENTOSE PHOSPHATE PATHWAY HEXOSE MONOPHOSPHATE SHUNT, PHOSPHOGLUCONATE PATHWAY LEHNINGER CHAP 14 PP 549-555 6-6 ALSO, PRODUCTION OF RIBOSE 5-PHOSPHATE FOR NUCLEOTIDE BIOSYNTHESIS ATP PRPP
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PURINE RING IS ASSEMBLED ON D-RIBOSE 5-PHOSPHATE FROM 7 PRECURSORS 17-5
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1: ASSEMBLY ON PRPP, NH3 FROM GLUTAMINE 17-6
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2: ADDITION OF GLYCINE, ATP FOR ACTIVATION 17-7
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N N CH2 l N- l O=CH N N H CH2 l N- H 5 10 3: ADDITION OF FORMATE (FOLATE) 17-8
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4: NH3 FROM GLUTAMINE 17-9
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5: CLOSURE OF IMIDAZOLE RING, ATP FOR ACTIVATION 17-10
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6: CARBOXYLATION (CO2), BUT BIOTIN-INDEPENDENT 17-11
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7: LIGATION OF ASPARTATE, ATP FOR ACTIVATION 17-12
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8: ELIMINATION OF FUMARATE, AS IN UREA CYCLE 17-13
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N N CH2 l N- l O=CH N N H CH2 l N- H 5 10 9: ADDITION OF FORMATE (FOLATE) 17-14
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10: RING CLOSURE: ADDITION, ELIMINATION OF H2O 17-15
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ADENINE AND GUANINE RINGS FROM INOSINE 17-16
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SYNTHESIS OF PYRIMIDE NUCLEOTIDES 17-17
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PYRIMIDINE BASE IS ASSEMBLED, THEN ATTACHED TO RIBOSE (PRPP) 17-18
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SYNTHESES OF 2’-DEOXYNUCLEOTIDES 17-19
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This note was uploaded on 01/29/2012 for the course MCB 354 taught by Professor Spees during the Spring '09 term at University of Illinois, Urbana Champaign.

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lecture 39___17 - MCB 354 Lecture 17 Nucleotide...

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