topic 1_rivier_252 - MCB 252 Cell Biology part 2 Prof David...

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MCB 252 Cell Biology, part 2 Prof. David Rivier Office hours: Mondays 2:00-3:00, MCB Learning Center Wednesdays 3:00-4:00, MCB Learning Center For questions on course material and science, see me in person, do not email me!!!
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MCB 252 Cell Biology, part 2 Advice: 1. Do reading before and after lecture 2. Keep up with material 3. Learn something from this experience: Life is more than grades! 4. Learning is more than cramming. 5. What’s important and how I make up exams 6. How lecture material is posted
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Reading for Rivier Lecture 1 (Introduction to part 2 of MCB 252) Lodish pp. 8-9, Lodish pp. 905-908, 911- 913
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Reading for Rivier Lecture 2 Techniques in Molecular & Cellular Biology Protein Purification pp. 96-98 X-ray Crystalography pp. 103-4 Immuno-flourescent Microscopy section 9.2 Antibodies pp. 400-401 Transfection and Transformation pp. 196-7 Transgenic Animals Figure 5-43 GFP pp. 197-8
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Reading for Topic 2: Lodish 17.0-17.2
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What do these people have in common? Elaine Fuchs Mark Krasnow Susan Lindquist Doug Melton Jamie Thomson
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Who is this guy?
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What is Science?
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Three Levels of Science 1. What we know (memorizing “facts”) Classes = an information dump 2. How we know what we know. 3. Asking new questions, seeking answers; making new hypotheses and testing them.
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MCB 252, part 2 Course philosophy and approach Outline of part 2 Topic 1a Intro and Discussion of “Big Picture” Topic 1b Molecular Techniques Topic 2 Cytoskeleton: Actin filaments
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MCB 252, part 2 Course outline Cytoskeleton, cell motility (9 lectures?) Cell-cell adhesion, cell-ECM interactions (5 lectures?) Cell cycle regulation (4 lectures?) Cancer (1-3 lectures?)
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MCB 252, part 2 Course outline Cytoskeleton, cell motility (9 lectures?) Cell-cell adhesion, cell-ECM interactions (5 lectures?) Cell cycle regulation (4 lectures?) Cancer (1-3 lectures?) Why do we care about these subjects??? Why are they important? Why spend our time asking question about these subjects? Start by thinking about tissues and organs
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Organs and Tissues Multicellular organisms form tissues and organs: specialized structures Bissell, 2003 Approximately 210 cell types in humans Approximately 100 trillion cells in an adult
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Organs and Tissues What properties do cells in tissues need to have in order for the organ/tissue to function properly?
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