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topic 3_rivier_252 - MCB 252 Cell Biology part 2 Topic 3...

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MCB 252 Cell Biology, part 2 Topic 3 Role of Actin in Cell Movement
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Reading Reading 1: Lodish 17.0- 17.2
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MCB 252 Actin Cytoskeleton A. Properties of Actin B. Role of Actin in Cell Movement C. Regulation of Actin Assembly in Cells D. Stable Actin Structures E. Muscle Cells and Myosin Motors
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Actin Cytoskeleton Properties of Actin Actin assembly Role of ATP Treadmilling Role of actin in cell movement Actin is required for movement Actin assembly can drive movement Regulation of actin assembly in cells Proteins invovled in actin assembly/disassembly Turning the protein invovled in assembly and disassembly ON and OFF
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Actin Polymarization Can Do Work G-actin -> F-actin + released energy Released energy can do work Work can result in membrane extension (Membrane extension requires work) G-actin -> F-actin + membrane extension
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Actin: stable structures and dynamic structures
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How do we know that actin polymerization is required for migration?
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