topic 5_rivier_252 - Filaments capped and relatively stable...

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MCB 252 Cell Biology Topic 5 Stable Actin Structures
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Reading Reading: Lodish 17.4
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MCB 252 Actin Cytoskeleton A. Properties of Actin B. Role of Actin in Cell Movement C. Regulation of Actin Assembly in Cells D. Stable Actin Structures E. Muscle Cells and Myosin Motors
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Actin Cytoskeleton Properties of Actin Actin assembly Role of ATP Treadmilling Role of acting in cell movement Actin is required for movement Actin assembly can drive movement Regulation of actin assembly in cells Proteins involved in actin assembly/disassembly Turning the protein involved in assembly and disassembly ON and OFF Building stable actin structures
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Actin Binding Proteins Cross-linking proteins interact with actin filaments to form bundles or networks Adaptor proteins link actin filaments to membranes
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Microvilli
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Microvilli From MCB 150
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Different Types of Bundles for Different Jobs
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Unformatted text preview: Filaments capped and relatively stable Red Blood Cells Must be “deformable” to squeeze through small capillaries RBC Cytoskeleton An ordered array of springs RBC Actin Cytoskeleton Note: these filaments are capped on both ends ( not shown) ERM Family Members Link Actin Cytoskeleton to Membrane Associated Proteins ERM = Ezrin, Radixin, Moesin Lots of Protein Families Interact with Actin Concepts 1. Why is actin highly conserved in evolution? “because” it has many functions and “because” interacts with many actin binding proteins 2. Invention is difficult, adaptation is easier…. . inventing a polymer is a rare event adapting a polymer to various functions is… … much easier (much more frequent). duplication and divergence is the primary mechanism of adaptation....
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topic 5_rivier_252 - Filaments capped and relatively stable...

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