topic 8_rivier_252 - MCB 252 Cell Biology Topic 8...

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Unformatted text preview: MCB 252 Cell Biology Topic 8 Microtubules Reading: Lodish 18.0-18.3 MCB 252, Part 2 Topic 8 Microtubules Microtubules Structure of monomer/polymer Dynamics of assembly Dynamic instability Microtubule-associated proteins (MAPs) Microtubule-based structures ciliated epithelium (oviduct) flagellum mitotic spindle Paramecium Centrosomes Spindle Poles Basal bodies In vivo imaging of mitotic spindles in Drosophila embryos Express GFP-Tau fusion protein in embryos; visualize with confocal microscopy Dr. Andrea Brand, Cambridge University, UK Movie: T8M1 06_cell_divisions.avi Microtubules First defined by EM (1963) Assembled from heterodimers of alpha- and beta-tubulin Dimers are stable, rarely dissociate alpha- and beta-tubulin ~40% identical residues Tubulins are highly conserved: >75% identical between plants and animals Structure of tubulin dimer Lodish, Fig. 18-3 non-exchangeable exchangeable Structure of tubulin polymer Lodish, Fig. 18-3 Polarity of tubulin polymerization Lodish, Fig. 18-9...
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This note was uploaded on 01/29/2012 for the course MCB 252 taught by Professor Wuebbles during the Spring '08 term at University of Illinois, Urbana Champaign.

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topic 8_rivier_252 - MCB 252 Cell Biology Topic 8...

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