topic 9_rivier_252 - MCB 252 Cell Biology Topic 9...

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MCB 252 Cell Biology Topic 9 Microtubule Organizing Centers Reading: Lodish 18.5 and the section of 18.6 titled “Centrosomes duplicate early in the cell cycle in preparation for mitosis”
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Microtubule-organizing centers (MTOCs) Spontaneous polymerization of MTs is highly unfavorable So, instead of spontaneous nucleation, cellular MTs arise from nucleation sites called microtubule-organizing centers Centrosomes, basal bodies
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Microtubule-organizing centers (MTOCs) Centrioles and Basal Bodies Lodish, Fig. 18-5 Cilia and Flagella
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Specialized MT Structures found in MTOCs, Cilia and Flagella 3 types of Microtubules
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MTOCs: Centriole and Basal Body Structure Array of 9 triplets
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Microtubule-organizing centers (MTOCs) Basal bodies at base of cilia and flagella Pollard and Earnshaw, Fig. 41-12 Basal body Axoneme Basal body
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Basal Bodies are Nucleation Centers for Axoneme Assembly Axoneme Basal Bodies Axoneme MTs are extensions Basal Bodies MTs Doublet extends from 2/3 MTs in Triplet Basal body caps and anchors minus ends of
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Structure of Cilia and Flagella Relation to Basal Body Lodish 18-29
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topic 9_rivier_252 - MCB 252 Cell Biology Topic 9...

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