topic 11_rivier_252 - MCB 252 Topic 11 Motors in Mitosis...

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MCB 252 Topic 11 Motors in Mitosis Reading: Lodish 18-6
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Roles of MTs in Interphase and Mitosis In Mitosis: 1.Cease Interphase Roles: Organelle transport and positioning 2. New Role: Attach to, Position, and Move Chromosomes
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Roles of MTs in Interphase and Mitosis What Happens During this Transition?
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Events in Mitosis
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Interphase/prophase Mitosis
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Fig. 12.5
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DNA Compaction: Spaghetti in a Sailboat 2 x 3 x 109 bp x .34 nm/bp = 2 meters DNA/nucleus Scale by 1,000,000: Nucleus 10m 10 meter sailboat DNA diameter 2 nm 2 millimeter DNA length 2 meters 2000 kilometers (1200 miles) UIUC to Orlando, Florida = 1066 miles
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Events in Mitosis
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Events in Mitosis, part 2
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Roles of MTs in Interphase and Mitosis In Mitosis: 1.Cease Interphase Roles: Organelle transport and positioning 2. New Role: Attach to, Position, and Move Chromosomes
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Regulation of Dynamic Instability in Mitosis Balance of MAPs v. Catastrophe Factors -> Dynamics Increased Gamma-TURC at centrosomes
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Three Classes of Mitotic Microtubules Kinetochore, Polar and Astral
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Chromosome Segregation- General Features
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Structure of Kinetichore by EM
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EM of MTs attached to the Kinetichore
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